Thrombospondin-1 Inhibits Vascular Endothelial Growth Factor Receptor-2 Signaling by Disrupting Its Association with Cd47*
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چکیده
RECEPTOR-2 SIGNALING BY DISRUPTING ITS ASSOCIATION WITH CD47* Sukhbir Kaur, Gema Martin-Manso, Michael L. Pendrak, Susan H. Garfield, Jeff S. Isenberg, and David D. Roberts 4 From the Laboratory of Pathology and Laboratory of Experimental Carcinogenesis, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892; Vascular Medicine Institute of the University of Pittsburgh, the Department of Medicine, and the Department of Pharmacology and Chemical Biology of the University of Pittsburgh, Pittsburgh, PA 15260 Running head: CD47 ligation controls VEGFR2 signaling Address correspondence to David D. Roberts, NIH, Building 10, Room 2A33, 10 Center Dr MSC1500, Bethesda, Maryland 20892 e-mail: [email protected]
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CD47 signaling regulates the immunosuppressive activity of VEGF in T cells.
Thrombospondin-1 (TSP1) inhibits angiogenesis, in part, by interacting with the ubiquitous cell-surface receptor CD47. In endothelial cells, CD47 interacts directly with vascular endothelial growth factor receptor (VEGFR)-2, and TSP1 inhibits VEGFR2 phosphorylation and signaling by disrupting this association. We show that CD47 similarly associates with and regulates VEGFR2 in T cells. TSP1 inh...
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